Intra-Alveolar Haemorrhage Complicating IgA Vasculitis: A Case Report, Literature Review and Discussion of Treatment
  • Benjamin Savoye
    Department of Internal Medicine and Clinical Immunology, CHU de Caen Côte de Nacre, Caen, France
  • Gwenola Maigne
    Department of Internal Medicine and Clinical Immunology, CHU de Caen Côte de Nacre, Caen, France
  • Evangeline Pillebout
    Department of Nephrology, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Descartes, Paris, France
  • Gaetane Planchard
    Department of Pathology, CHU de Caen Côte de Nacre, Caen, France
  • Maxime Faisant
    Department of Pathology, CHU de Caen Côte de Nacre, Caen, France
  • Achille Aouba
    Department of Internal Medicine and Clinical Immunology, CHU de Caen Côte de Nacre, Caen, France
  • Alexandra Audemard
    Department of Internal Medicine and Clinical Immunology, CHU de Caen Côte de Nacre, Caen, France

Keywords

IgA vasculitis, Henoch-Schönlein purpura, intra-alveolar haemorrhage, cancer

Abstract

Introduction: Immunoglobulin A vasculitis (IgAV) is a small-vessel vasculitis with IgA-dominant immune deposits. IgAV frequently involves the skin, gastrointestinal tract, joints and kidneys. In contrast to other types of small-vessel vasculitis, IgAV is rarely complicated by intra-alveolar haemorrhage (IAH).
Methods/Results: We describe a patient with relapsing bladder cancer who presented with IAH during the course of IgAV successfully treated with corticosteroids alone.
Conclusion: This case report reminds us that IgAV can manifest with IAH. There are no robust data to support the systematic use of cyclophosphamide or plasma exchange as first-line therapy for IgAV with IAH.

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References

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  • Pillebout E, Alberti C, Guillevin L, Ouslimani A, Thervet E. Addition of cyclophosphamide to steroids provides no benefit compared with steroids alone in treating adult patients with severe Henoch Schonlein purpura. Kidney Int 2010;78:495–502.

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    Published: 2019-03-25
    Issue: Vol 6 No 4 (view)


    How to cite:
    1.
    Savoye B, Maigne G, Pillebout E, Planchard G, Faisant M, Aouba A, Audemard A. Intra-Alveolar Haemorrhage Complicating IgA Vasculitis: A Case Report, Literature Review and Discussion of Treatment. EJCRIM 2019;6 doi:10.12890/2019_001083.