Central giant cell granuloma: An uncommon presentation

https://doi.org/10.1016/j.omsc.2018.08.001Get rights and content
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Highlights:

  • Central giant Cell Granuloma is a benign, proliferative, intraosseous and non-odontogenic lesion of unknown etiology.

  • Females have higher incidence with lesions occurring predominantly during the first 3 decades of life.

  • This report describes a rare presentation occurring in a 45yr old female with an edentulous mandible.

  • Various differential diagnoses were considered due to the unusual age, posing both a diagnostic and surgical challenge.

  • A treatment consisting of surgical curettage with reconstruction and local delivery of steroid was done.

Abstract

Central giant cell granuloma is a benign, non odontogenic lesion accounting for fewer than 7% of all benign tumors of the jaws. It commonly occurs in anterior mandible with a female prediction in ages below 30yrs. Multiple treatment modalities have been used with varying degrees of success, there is no accepted algorithm for therapeutic intervention. Surgical treatment has been the traditional accepted modality reducing chances of recurrence. Non-surgical treatments with alpha interferon (a-IFN), calcitonin, Denosumab and corticosteroids have been described in literature as adjuvants or as definitive treatments. This case report reviews presentation and currently used therapies for CGCG while describing a uncommon case of central giant cell granuloma occurring in a 45 year old female who presented with a swelling in relation to the left edentulous mandible. Surgical curettage of the lesion along with reconstruction and local delivery of steroid in the cavity was done allowing for the best esthetic and functional result with no recurrence during follow up.

Keywords

Central giant cell granuloma
Edentulous mandible
Surgical curettage
Steroids

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